Description
Product Characteristics:
The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains, however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
Subcellular location: Cell membrane
Synonyms: AIP 3, AIP3, Atrophin 1 interacting protein 3, atrophin-1 interacting protein 3, BAI associated protein 2, BAI1 associated protein 1, BAI1-associated protein 1, BAIAP 1, BAIAP1, BAP 1, BAP1, BAP2, Brain specific angiogenesis inhibitor 1 associated protein 2, Fas ligand associated factor 3, FLAF3,Gukmi1, Insulin receptor substrate p53, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, IRS 58, IRSP53, IRSp53/58, MAGI 1, MAGI-1, MAGI1c, Membrane associated guanylate kinase inverted 1, membrane associated guanylate kinase inverted-1, membrane associated guanylate kinase WW and PDZ domain containing 1, Protein BAP2, TNRC 19, TNRC19, Trinucleotide repeat containing gene 19, Trinucleotide repeat containing gene 19 protein,trinucleotide repeat-containing gene 19, WW domain containing protein 3, WW domain-containing protein 3, WWP 3, WWP3.
Target Information: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]